Overview
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
Most Useful Reviews
9
Essential for energy
Vitamin B12 is vital for maintaining a healthy nervous system and supports energy generation from nutrients. It aids in cardiovascular health and the synthesis of DNA, important for blood cells. I find its quality and results excellent.
Read More
7.5
Supports health
Vitamin B12 is beneficial for my nervous system and helps support cardiovascular health.
Read More
7.5
Improved mood
Vitamin B12 has helped alleviate fatigue, anxiety, and drowsiness. I noticed an improvement in my mood and energy levels. I prefer taking it as a chewable tablet, which is enjoyable and effective for my cardiovascular health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
- All Researches
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
We investigated how exposure to metal mixtures during pregnancy influences blood pressure and hypertension later in life.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Read More
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for energy
Vitamin B12 is vital for maintaining a healthy nervous system and supports energy generation from nutrients. It aids in cardiovascular health and the synthesis of DNA, important for blood cells. I find its quality and results excellent.
Read More
7.5
Supports health
Vitamin B12 is beneficial for my nervous system and helps support cardiovascular health.
Read More
7.5
Improved mood
Vitamin B12 has helped alleviate fatigue, anxiety, and drowsiness. I noticed an improvement in my mood and energy levels. I prefer taking it as a chewable tablet, which is enjoyable and effective for my cardiovascular health.
Read More
Frequently Asked Questions
7.5
Improved mood
Vitamin B12 has helped alleviate fatigue, anxiety, and drowsiness. I noticed an improvement in my mood and energy levels. I prefer taking it as a chewable tablet, which is enjoyable and effective for my cardiovascular health.
9
Essential for energy
Vitamin B12 is vital for maintaining a healthy nervous system and supports energy generation from nutrients. It aids in cardiovascular health and the synthesis of DNA, important for blood cells. I find its quality and results excellent.
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
7
We examined a unique case involving a 57-year-old man who experienced a myocardial infarction due to coronary artery spasm. His condition was associated with high serum homocysteine levels and low vitamin B12. Following treatment with vitamin B12 and calcium channel antagonists, his homocysteine levels normalized, and he reported no further chest pain or spasm.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
7
We investigated how blood levels of B vitamins, particularly B6 and B12, influence blood pressure variability (BPV) in individuals with essential hypertension.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
References
- Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008
- Ikeda A, Akama J, Ohki Y, Kunii H, Saitoh SI. Myocardial infarction with non-obstructive coronary artery caused by coronary artery spasm and an increase in serum homocysteine: a case report. Eur Heart J Case Rep. 2025;9:ytaf118. doi:10.1093/ehjcr/ytaf118
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. doi:10.26402/jpp.2025.1.02
- Zhang M, Aris IM, Cardenas A, Rifas-Shiman SL, Lin PD, et al. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study. Hypertension. 2025. doi:10.1161/HYPERTENSIONAHA.124.23980
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. doi:10.1016/j.clnesp.2024.11.034
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. doi:10.1038/s41598-024-77437-z
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
